Identification of causative mutations in patients with Leigh syndrome and MERRF by mitochondrial DNA-targeted next-generation sequencing
نویسندگان
چکیده
منابع مشابه
Identification of causative mutations in patients with Leigh syndrome and MERRF by mitochondrial DNA- targeted next-generation sequencing
in the mitochondrial DNA (mtDNA) that lead to oxidative phosphorylation impairment, ATP depletion, cellular dysfunction, and ultimately cell death [1]. Most mitochondrial diseases involve impairment of multiple organs, particularly in tissues with a high energy demand such as nerve and muscle. Identification of causative mutations in patients with Leigh syndrome and MERRF by mitochondrial DNAta...
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ژورنال
عنوان ژورنال: Journal of Genetic Medicine
سال: 2015
ISSN: 1226-1769,2383-8442
DOI: 10.5734/jgm.2015.12.2.109